Effect of Perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction
Date
2004
Authors
Chirkov, Y.
Holmes, A.
Martelli, J.
Horowitz, J.
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Journal article
Citation
American Journal of Cardiology, 2004; 93(11):1438-1440
Statement of Responsibility
Yuliy Y. Chirkov, Andrew S. Holmes, Jason D. Martelli, and John D. Horowitz
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Abstract
In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.
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Copyright © 2004 Excerpta Medica Inc. All rights reserved.