Current studentsExisting staffContact us
 

Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep

Simple item page
dc.contributor.authorEdwards, L.
dc.contributor.authorMcMillen, I.C.
dc.date.issued2002
dc.description.abstractIt has been proposed that fetal adaptations to intrauterine nutrient deprivation permanently reprogram the cardiovascular system. We investigated the impact of restricted periconceptional nutrition and/or restricted gestational nutrition on fetal arterial blood pressure (BP), heart rate, rate pressure product, and the fetal BP responses to ANG II and the angiotensin-converting enzyme inhibitor captopril during late gestation. Restricted periconceptional nutrition resulted in an increase in fetal mean arterial BP between 115 and 125 days gestation (restricted 41.5 +/- 2.8 mmHg, n = 12; control 38.5 +/- 1.5 mmHg, n = 13) and between 135 and 147 days gestation (restricted 50.5 +/- 2.2 mmHg, n = 8; control 42.5 +/- 1.9 mmHg, n = 10) as well as an increase in the rate pressure product in twin, but not singleton, fetuses between 115 and 147 days gestation. Mean BP and fetal plasma ACTH were also positively correlated in twin, but not singleton, fetuses. This is the first demonstration that maternal undernutrition during the periconceptional period results in an increase in fetal arterial BP. This increase occurs concomitantly with an increase in fetal ACTH but is not dependent on activation of the fetal renin-angiotensin system.
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2002; 283(3 52-3):R669-R679
dc.identifier.doi10.1152/ajpregu.00736.2001
dc.identifier.issn0363-6119
dc.identifier.issn1522-1490
dc.identifier.urihttps://hdl.handle.net/1959.8/44199
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1152/ajpregu.00736.2001
dc.subjectMyocardium
dc.subjectCardiovascular System
dc.subjectAnimals
dc.subjectSheep
dc.subjectPlacental Insufficiency
dc.subjectOxygen
dc.subjectHydrocortisone
dc.subjectCaptopril
dc.subjectAngiotensin II
dc.subjectVasoconstrictor Agents
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectOxygen Consumption
dc.subjectRenin-Angiotensin System
dc.subjectPregnancy
dc.subjectBlood Pressure
dc.subjectHeart Rate
dc.subjectFemale
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnimal Nutritional Physiological Phenomena
dc.titlePericonceptional nutrition programs development of the cardiovascular system in the fetal sheep
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915912669701831

Files

Collections