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Posttraumatic Stress Disorder, Antipsychotic Use and Risk of Dementia in Veterans

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dc.contributor.authorRoughead, E.E.
dc.contributor.authorPratt, N.L.
dc.contributor.authorKalisch Ellett, L.M.
dc.contributor.authorRamsay, E.N.
dc.contributor.authorBarratt, J.D.
dc.contributor.authorMorris, P.
dc.contributor.authorKiller, G.
dc.date.issued2017
dc.descriptionData source: Supporting information, http://onlinelibrary.wiley.com/store/10.1111/jgs.14837/asset/supinfo/jgs14837-sup-0001-AppendixS1-3.docx?v=1&s=2c7bca0e6e0918d452b8f64ee0ab207995c64b41
dc.description.abstractTo examine the risk of dementia associated with posttraumatic stress disorder (PTSD) and the contribution of antipsychotic use to this risk.Retrospective cohort study SETTING: Australia. Administrative claims data from the Australian Government Department of Veterans' Affairs were used.Male Vietnam veterans aged 55 to 65 at baseline (2001-02) with no preexisting dementia diagnosis (N = 15,612).The association between PTSD and dementia was assessed over 12 years of follow-up. Dementia was identified as a hospital diagnosis, dementia record in service disability data, or dispensing of medicines for dementia. Cox-proportional hazards models were used, with age as the time-scale. Results were stratified according to baseline antipsychotic use.No greater risk of dementia was observed with PTSD. In veterans who received antipsychotics, dementia risk was significantly higher than in those who did not (hazard ratio (HR) = 2.1, 95% confidence interval (CI) = 1.4-3.3). Dementia risk was significantly greater in veterans hospitalized for PTSD who received antipsychotics (HR = 2.2, 95% CI = 1.1-4.6) and veterans without PTSD who received antipsychotics (HR = 4.3, 95% CI = 2.1-8.6) than in those without PTSD with no antipsychotic use.Antipsychotic use may be a contributor to dementia risk. These findings should be interpreted with caution because the study design was observational. Further research using prospective study designs in settings where diagnostic data, cognitive function, and disease severity are available are required.
dc.identifier.citationJournal of The American Geriatrics Society, 2017; 65(7):1521-1526
dc.identifier.doi10.1111/jgs.14837
dc.identifier.issn0002-8614
dc.identifier.issn1532-5415
dc.identifier.orcidPratt, N.L. [0000-0001-8730-8910]
dc.identifier.orcidKalisch Ellett, L.M. [0000-0001-5063-6128]
dc.identifier.orcidRamsay, E.N. [0000-0002-8708-5910]
dc.identifier.urihttps://hdl.handle.net/11541.2/127546
dc.language.isoen
dc.publisherWILEY
dc.relation.fundingAustralian Government Department of Veterans’ Affairs (DVA)
dc.rightsCopyright 2017 the Authors, Journal compilation copyright 2017, The American Geriatrics Society Access Condition Notes: Postprint available after 1 October 2018
dc.source.urihttps://doi.org/10.1111/jgs.14837
dc.subjectHumans
dc.subjectDementia
dc.subjectAntipsychotic Agents
dc.subjectRisk Factors
dc.subjectRetrospective Studies
dc.subjectStress Disorders, Post-Traumatic
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectVeterans
dc.subjectAustralia
dc.subjectMale
dc.titlePosttraumatic Stress Disorder, Antipsychotic Use and Risk of Dementia in Veterans
dc.typeJournal article
pubs.publication-statusPublished
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ror.mmsid9916138185901831

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