Cytomegalovirus and Epstein–Barr virus may be associated with some cases of cerebral palsy

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dc.contributor.authorMcMichael, G.
dc.contributor.authorMacLennan, A.
dc.contributor.authorGibson, C.
dc.contributor.authorAlvino, E.
dc.contributor.authorGoldwater, P.
dc.contributor.authorHaan, E.
dc.contributor.authorDekker, G.
dc.date.issued2012
dc.description.abstractObjective: Intrauterine infection is a risk factor for cerebral palsy. Previous work reported a high frequency of viral DNA in newborn screening cards from cerebral palsy cases and controls possibly due to contamination. Methods: Retrospective case-control study using improved methodologies to minimize contamination during PCR-based detection of viral DNA sequences. Newborn screening cards of 339 Caucasian children with cerebral palsy and 594 controls were examined. Viruses tested were herpes simplex viruses 1 and 2 (HSV1 and 2), varicella zoster virus (VZV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), human herpes viruses 6, 7 and 8 (HHV6, HHV7 and HHV8), and parvovirus B19. Genotyping was performed on DNA extracted from dried blood spots. Results: CMV and EBV were detected in 5 (1.5%) and 3 (0.9%) of 339 cases, respectively, but not in controls (p  = 0.047 and 0.006). Frequencies of detection of the other viruses examined were similar for cases and controls. DNA from at least one of the nine viruses tested was found in 4.4% of cases and 3.1% of controls [OR 1.4 95% CI (0.71–2.76)]. Conclusion: Evidence of congenital viral infection was uncommon in cases of cerebral palsy and controls. However, CMV and EBV were significantly associated with cerebral palsy.
dc.description.statementofresponsibilityGai McMichael, Alastair MacLennan, Catherine Gibson, Emily Alvino, Paul Goldwater, Eric Haan, Gustaaf Dekker
dc.identifier.citationThe Journal of Maternal-Fetal and Neonatal Medicine, 2012; 25(10):2078-2081
dc.identifier.doi10.3109/14767058.2012.666587
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.orcidMcMichael, G. [0000-0002-6811-5301]
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.urihttp://hdl.handle.net/2440/71207
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.source.urihttps://doi.org/10.3109/14767058.2012.666587
dc.subjectAustralian Collaborative Cerebral Palsy Research Group
dc.subjectHumans
dc.subjectCytomegalovirus
dc.subjectHerpesvirus 4, Human
dc.subjectCytomegalovirus Infections
dc.subjectEpstein-Barr Virus Infections
dc.subjectCerebral Palsy
dc.subjectDNA, Viral
dc.subjectNeonatal Screening
dc.subjectCase-Control Studies
dc.subjectRetrospective Studies
dc.subjectPolymerase Chain Reaction
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant, Newborn
dc.subjectDried Blood Spot Testing
dc.titleCytomegalovirus and Epstein–Barr virus may be associated with some cases of cerebral palsy
dc.typeJournal article
pubs.publication-statusPublished

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