Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

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dc.contributor.authorKennedy, B.
dc.contributor.authorMclaughlin, R.
dc.contributor.authorKennedy, K.
dc.contributor.authorChin, L.
dc.contributor.authorCuratolo, A.
dc.contributor.authorTien, A.
dc.contributor.authorLatham, B.
dc.contributor.authorSaunders, C.
dc.contributor.authorSampson, D.
dc.date.issued2014
dc.description.abstractWe present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 με. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology.
dc.description.statementofresponsibilityBrendan F. Kennedy, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Andrea Curatolo, Alan Tien, Bruce Latham, Christobel M. Saunders and David D. Sampson
dc.identifier.citationBiomedical Optics Express, 2014; 5(7):2113-2124
dc.identifier.doi10.1364/BOE.5.002113
dc.identifier.issn2156-7085
dc.identifier.issn2156-7085
dc.identifier.orcidMclaughlin, R. [0000-0001-6947-5061]
dc.identifier.urihttp://hdl.handle.net/2440/106197
dc.language.isoen
dc.publisherOptical Society of America
dc.relation.grantARC
dc.rights© 2014 Optical Society of America
dc.source.urihttps://doi.org/10.1364/boe.5.002113
dc.subject(100.5088) Phase unwrapping
dc.subject(110.1650) Coherence imaging
dc.subject(110.4500) Optical coherence tomography
dc.titleOptical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
dc.typeJournal article
pubs.publication-statusPublished

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