Multilineage involvement and erythropietin - "independent" erythroid progenitor cells in a patient with systemic mastrocytosis
Date
1998
Authors
Afonja, O.
Amorosi, E.
Ashman, Leonie Kay
Takeshita, K.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Annals of Hematology, 1998; 77(4):183-186
Statement of Responsibility
O. Afonja, E. Amorosi, L. Ashman, K. Takeshita
Conference Name
Abstract
We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-"independent" erythroid progenitor cells.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© Springer-Verlag 1998