Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis

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dc.contributor.authorBain, M.
dc.contributor.authorFaull, R.
dc.contributor.authorFornasini, G.
dc.contributor.authorMilne, R.
dc.contributor.authorEvans, A.
dc.date.issued2006
dc.description.abstract<h4>Background</h4>Trimethylamine (TMA) is a short-chain tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods high in TMA or by the intake of food high in precursors to TMA, such as trimethylamine-N-oxide (TMNO), choline and L-carnitine. The clinical significance of TMA may be related to its potential to contribute to neurological toxicity and 'uraemic breath' in patients with end-stage renal disease (ESRD).<h4>Methods</h4>Concentrations of TMA and TMNO in plasma from 10 healthy adults (not on haemodialysis) and 10 adults with ESRD undergoing haemodialysis (pre- and post-dialysis) were determined by gas chromatography-mass spectrometry.<h4>Results</h4>The concentrations of TMA and TMNO in pre-dialysis plasma (1.39+/-0.483 and 99.9+/-31.9 microM, respectively) were significantly (P<0.05) higher than the corresponding levels in healthy subjects (0.418+/-0.124 and 37.8+/-20.4 microM, respectively). However, there were no significant differences between post-dialysis and healthy subject plasma concentrations. In the ESRD patients, there was a significant (P<0.05) reduction in plasma TMA (from 1.39+/-0.483 to 0.484+/-0.164 microM) and TMNO (from 99.9+/-31.9 to 41.3+/-18.8 microM) during a single haemodialysis session.<h4>Conclusions</h4>TMA and TMNO accumulate between haemodialysis sessions in ESRD patients, but are efficiently removed during a single haemodialysis session.
dc.description.statementofresponsibilityMarcus A. Bain, Randall Faull, Gianfranco Fornasini, Robert W. Milne, and Allan M. Evans
dc.identifier.citationNephrology Dialysis Transplantation, 2006; 21(5):1300-1304
dc.identifier.doi10.1093/ndt/gfk056
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.urihttp://hdl.handle.net/2440/23367
dc.language.isoen
dc.publisherOxford Univ Press
dc.rights© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
dc.source.urihttps://doi.org/10.1093/ndt/gfk056
dc.subjectend-stage renal disease
dc.subjectgas chromatography
dc.subjecttrimethylamine
dc.subjecttrimethylamine-N-oxide
dc.titleAccumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis
dc.typeJournal article
pubs.publication-statusPublished

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