Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays

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dc.contributor.authorGulati, K.
dc.contributor.authorAw, M.
dc.contributor.authorFindlay, D.
dc.contributor.authorLosic, D.
dc.date.issued2012
dc.description.abstractTitania nanotube (TNT) arrays fabricated by electrochemical anodization of titanium are currently one of the most attractive nanomaterials due to their remarkable properties. In this review, we highlight recent research activities that are focused on the application of the TNT arrays for local drug delivery, specifically for addressing problems associated with orthopedic implants. The advantages of drug-releasing implants based on TNT arrays for local delivery of therapeutics in bone related to these challenging problems including inflammation, infection and osseointegration are discussed. An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented.
dc.description.statementofresponsibilityKaran Gulati, Moom Sinn Aw, David Findlay and Dusan Losic
dc.identifier.citationTherapeutic Delivery, 2012; 3(7):857-873
dc.identifier.doi10.4155/tde.12.66
dc.identifier.issn2041-5990
dc.identifier.issn2041-6008
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]
dc.identifier.urihttp://hdl.handle.net/2440/76675
dc.language.isoen
dc.publisherFuture Science Ltd
dc.relation.granthttp://purl.org/au-research/grants/arc/DP 120101680
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.4155/tde.12.66
dc.subjectBone and Bones
dc.subjectAnimals
dc.subjectHumans
dc.subjectBone Diseases
dc.subjectTitanium
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectAnti-Inflammatory Agents
dc.subjectBiocompatible Materials
dc.subjectDrug Implants
dc.subjectDrug Carriers
dc.subjectAnti-Infective Agents
dc.subjectTechnology, Pharmaceutical
dc.subjectDrug Compounding
dc.subjectOsseointegration
dc.subjectChemistry, Pharmaceutical
dc.subjectNanotubes
dc.subjectNanomedicine
dc.titleLocal drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays
dc.typeJournal article
pubs.publication-statusPublished

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