Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis

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dc.contributor.authorGrover, P.
dc.contributor.authorHardingham, J.
dc.contributor.authorCummins, A.
dc.date.issued2010
dc.description.abstractOlfactomedin 4 (OLFM4), a member of the olfactomedin domain-containing proteins, is a glycoprotein with molecular weight of approximately 64 kDa. The protein is a "robust marker" of Lgr5+ stem cells and has been localised to mitochondria, nuclei and cell membranes. The bulk of OLFM4 exists in a polymeric form which is held together by disulfide bonds and carbohydrate interactions. Earlier studies revealed that the protein binds to lectins and cadherins, and facilitates cell-cell adhesion. Recent data demonstrated that the protein possesses several hallmarks of carcinogenesis. OLFM4 has also been purported to be an inducible resistance factor to apoptotic stimuli such as radiation and anticancer drugs. Here, we review its synonyms and classification, gene structure, protein structure, intracellular and tissue distribution, adhesive and antiapoptotic; mitotic; migratory and cell cycle regulatory characteristics. We also critically evaluate recent advances in understanding of the transcriptional regulation of OLFM4 and its upstream signalling pathways with special emphasis on carcinogenesis and outline future perspectives in the field.
dc.description.statementofresponsibilityPhulwinder K. Grover, Jennifer E. Hardingham, Adrian G. Cummins
dc.identifier.citationCancer and Metastasis Reviews, 2010; 29(29):761-775
dc.identifier.doi10.1007/s10555-010-9262-z
dc.identifier.issn1573-7233
dc.identifier.issn1573-7233
dc.identifier.orcidHardingham, J. [0000-0001-8277-1199]
dc.identifier.orcidCummins, A. [0000-0003-3115-9498]
dc.identifier.urihttp://hdl.handle.net/2440/63983
dc.language.isoen
dc.publisherSpringer New York LLC
dc.rights© Springer Science+Business Media, LLC 2010
dc.source.urihttps://doi.org/10.1007/s10555-010-9262-z
dc.subjectOlfactomedin 4
dc.subjectAntiapoptotic
dc.subjectMitotic
dc.subjectCell cycle regulatory
dc.subjectMigratory
dc.subjectTumorigenic
dc.titleStem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis
dc.typeJournal article
pubs.publication-statusPublished

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