Phases of reprogramming
Date
2014
Authors
David, L.
Polo, J.M.
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Journal article
Citation
Stem Cell Research, 2014; 12(3):754-761
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Laurent David, Jose M. Polo
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Abstract
Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to a greater extent, defined and controlled. Herein, we will review the key cellular and molecular events associated with the reprogramming process, giving an integrative and conciliatory view of the different studies addressing the mechanism of nuclear reprogramming.
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© 2014 Published by Elsevier B.V.