The role of tachykinins in airway inflammation and bronchial hyper-responsiveness / Paul N. Reynolds.
| dc.contributor.author | Reynolds, Paul Nigel | en |
| dc.contributor.school | Dept. of Medicine | en |
| dc.date.issued | 1999 | en |
| dc.description | Bibliography: leaves 217-244. | en |
| dc.description | x, 246 leaves : ill. (chiefly col.) ; 30 cm. | en |
| dc.description.abstract | Tachykinins are implicated in the mediation of airway inflammatory responses and may have roles in airway remodeling and healing. The actions of tachykinins are mediated by specific receptors, designated NK1, NK2 and NK3. Tachykinin degredation, an important mechanism for limiting the effects of these peptides, is principally mediated by neutral endopeptidase (NEP). This thesis investigates the role of tachykinins, in vivo, in an ovine model and in human airway epithelium. Results show that the nett effect of tachykinins in the airway will depend on the relative balance between the expression of receptors, tachykinins and NEP. Assessment of these molecules in the airway epithelium from subjects with normal lungs or chronic bronchitis showed that preprotachykinin-A gene expression was relatively higher in the disease group whereas NEP and NK1 receptor levels were unchanged. These studies provide new insights into the role of tachykinins in airways disease. | en |
| dc.description.dissertation | Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1999 | en |
| dc.format.extent | 285102 bytes | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.uri | http://hdl.handle.net/2440/19548 | |
| dc.language.iso | en | en |
| dc.provenance | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals | |
| dc.subject.lcsh | Tachykinins. | en |
| dc.subject.lcsh | Respiratory organs Diseases. | en |
| dc.title | The role of tachykinins in airway inflammation and bronchial hyper-responsiveness / Paul N. Reynolds. | en |
| dc.type | Thesis | en |