Clinical and genetic associations of autoantibodies to 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in patients with immune-mediated myositis and necrotizing myopathy

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dc.contributor.authorLimaye, V.
dc.contributor.authorBundell, C.
dc.contributor.authorHollingsworth, P.
dc.contributor.authorRojana-Udomsart, A.
dc.contributor.authorMastaglia, F.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorLester, S.
dc.date.issued2015
dc.description.abstractIntroduction: Inhibition of 3-hydroxy-3-methylglutaryl- coenzyme A reductase (HMGCR) with statins may trigger idiopathic inflammatory myositis (IIM) or immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR antibodies have been detected in patients with IIM/IMNM. We aimed to determine the associations of anti-HMGCR in IIM/IMNM. Methods: Anti-HMGCR antibodies were detected by ELISA in sera from patients with IIM/IMNM. Results: Anti-HMGCR antibodies were detected in 19 of 207 patients with IIM/IMNM, and there was a trend toward an association with male gender (P50.079). Anti- HMGCR antibodies were associated strongly with statin exposure (OR539, P50.0001) and HLA-DRB1*11 (OR550, P<0.0001). The highest risk for development of anti-HMGCR antibodies was among HLA-DR11 carriers exposed to statins. Univariate analysis showed a strong association of anti- HMGCR antibodies with diabetes mellitus (P50.008), which was not confirmed by multiple regression. Among anti- HMGCR⁺ patients there was a trend toward increased malignancy (P50.15). Conclusions: Anti-HMGCR antibodies are seen in all subtypes of IIM and IMNM and are associated strongly with statin use and HLA-DR11.
dc.description.statementofresponsibilityVidya Limaye, Chris Bundell, Peter Hollingsworth, Arada Rojana-Udomsart, Frank Mastaglia, Peter Blumbergs and Sue Lester
dc.identifier.citationMuscle and Nerve, 2015; 52(2):196-203
dc.identifier.doi10.1002/mus.24541
dc.identifier.issn0148-639X
dc.identifier.issn1097-4598
dc.identifier.orcidLimaye, V. [0000-0002-8142-9532]
dc.identifier.orcidLester, S. [0000-0003-3013-2701]
dc.identifier.urihttp://hdl.handle.net/2440/112710
dc.language.isoen
dc.publisherWiley
dc.rights© 2014 Wiley Periodicals, Inc.
dc.source.urihttps://doi.org/10.1002/mus.24541
dc.subjectAntibodies; HMG-CoA reductase; immune-mediated necrotizing myopathy; muscle biopsy; myositis; statins
dc.titleClinical and genetic associations of autoantibodies to 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in patients with immune-mediated myositis and necrotizing myopathy
dc.typeJournal article
pubs.publication-statusPublished

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