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Reactivation of telomerase in cancer

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dc.contributor.authorAkincilar, S.C.
dc.contributor.authorUnal, B.
dc.contributor.authorTergaonkar, V.
dc.date.issued2016
dc.description.abstractActivation of telomerase is a critical step in the development of about 85 % of human cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are limiting in normal somatic cells. Tert is subjected to transcriptional, post-transcriptional and epigenetic regulation, but the precise mechanism of how telomerase is re-activated in cancer cells is poorly understood. Reactivation of the Tert promoter involves multiple changes which evolve during cancer progression including mutations and chromosomal re-arrangements. Newly described non-coding mutations in the Tert promoter region of many cancer cells (19 %) in two key positions, C250T and C228T, have added another layer of complexity to telomerase reactivation. These mutations create novel consensus sequences for transcription factors which can enhance Tert expression. In this review, we will discuss gene structure and function of Tert and provide insights into the mechanisms of Tert reactivation in cancers, highlighting the contribution of recently identified Tert promoter mutations.
dc.identifier.citationCellular and Molecular Life Sciences, 2016; 73(8):1659-1670
dc.identifier.doi10.1007/s00018-016-2146-9
dc.identifier.issn1420-682X
dc.identifier.issn1420-9071
dc.identifier.urihttps://hdl.handle.net/11541.2/118999
dc.language.isoen
dc.publisherSpringer
dc.relation.fundingAgency for Science Technology and Research, Singapore (A*STAR)
dc.rightsCopyright 2016 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1007/s00018-016-2146-9
dc.subjectTERT reactivation
dc.subjectNF-κB
dc.subjectTert promoter mutation
dc.subjecttranscription
dc.subjectancer
dc.titleReactivation of telomerase in cancer
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12143307320001831 13143305390001831 9916069306101831_53133097840001831.pdf
ror.mmsid9916069306101831

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