Translation from clinical trials to routine practice: How to demonstrate community benefit
Date
2015
Authors
Roder, D.
Buckley, E.
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Journal article
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Asia-Pacific Journal of Clinical Oncology, 2015; 11(1):1-3
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The paper by Lok et al. in the APJCO December issue demonstrates the use of a clinical database for assessing research translation.[1] It shows uptake of treatments proven to be effective in earlier clinical trials and improved survival for metastatic colorectal cancer at four major Melbourne hospitals.[1-4] It is important as population benefits from trials depend on research translation.Even with vigorous research translation into clinical practice, outcomes may not reflect trial results due to differences in clinical environments and patient profiles.[5-7] For pragmatic reasons, trials may involve clinical centers where specialist interest is high, and larger centers where stronger infrastructure support exists, but the relevance of results to the broader community may be questionable.[6, 7] Trials often exclude patients with significant comorbidity or age-related frailty to gain a clearer view of treatment efficacy under optimal conditions, but this can raise questions about the generalizability of results to excluded groups.[5-7] Moreover, while it may be feasible to optimize clinical rigor within a trial environment, this rigor may be difficult to maintain in all routine practice settings
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Copyright 2015 Wiley Publishing Asia Pty Ltd