Systematic evolution of ligands by exponential enrichment: tissue selex
Date
1999
Authors
Jensen, K.
Chen, H.
Morris, K.N.
Stephens, A.
Gold, L.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Patent
Citation
Statement of Responsibility
Inventors: Jensen Kirk, Chen Hang, Morris Kevin N., Stephens Andrew, Gold Larry. Assignee: NeXstar Pharmaceuticals, Inc. Agents: Swanson & Bratschun LLC
Conference Name
Abstract
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
School/Discipline
Dissertation Note
Provenance
Description
Publication number US5864026 A
Publication type Grant
Application number US 08/437,667
Publication date Jan 26, 1999
Filing date May 3, 1995
Priority date Jun 11, 1990