Granulocyte-macrophage colony stimulating factor (GM-CSF): one of a family of epithelial cell-derived cytokines in the preimplantation uterus

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dc.contributor.authorRobertson, S.A.
dc.contributor.authorSeamark, R.F.
dc.date.issued1992
dc.description.abstractGranulocyte-macrophage colony stimulating factor (GM-CSF) is one of a number of lympho-haemapoietic cytokines, including CSF-1, interleukin-6 (IL-6) and leukaemia inhibitory factor (LIF) now known to be synthesized by epithelial cells in the murine uterus. GM-CSF synthesis is regulated primarily by the ovarian steroid hormone oestrogen, but is also subject to modulation by factors including a seminal component of seminal vesicle origin which stimulates a 20-fold increase in luminal fluid content at mating, and bacterial lipopolysaccharide (LPS) and the T-lymphocyte and natural killer (NK) cell product interferon-gamma (IFN gamma). In the non-pregnant mouse GM-CSF synthesis peaks at oestrus. Synthesis is maintained at comparable or moderately higher levels during the preimplantation period of pregnancy and in the non-decidualized endometrium during mid gestation. An embryotrophic activity is suggested by studies in vitro that indicate that GM-CSF stimulates attachment and outgrowth of blastocysts. It is postulated that GM-CSF is of major importance to the physiology of pregnancy through its role as a component of a local cytokine circuit acting to recruit and regulate function of endometrial leukocytes, and by its action as interlocutor and important effector arm in embryo-maternal interactions during gestation.
dc.description.statementofresponsibilitySA Robertson and RF Seamark
dc.identifier.citationReproduction Fertility and Development, 1992; 4(4):435-448
dc.identifier.doi10.1071/RD9920435
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.orcidRobertson, S.A. [0000-0002-9967-0084]
dc.identifier.urihttp://hdl.handle.net/2440/85260
dc.language.isoen
dc.publisherCSIRO Publishing
dc.rights© CSIRO 1992
dc.source.urihttps://doi.org/10.1071/rd9920435
dc.subjectUterus
dc.subjectLeukocytes
dc.subjectAnimals
dc.subjectHumans
dc.subjectSteroids
dc.subjectGranulocyte-Macrophage Colony-Stimulating Factor
dc.subjectCytokines
dc.subjectEmbryonic and Fetal Development
dc.subjectEmbryonic Development
dc.subjectPregnancy
dc.subjectFemale
dc.subjectIn Vitro Techniques
dc.titleGranulocyte-macrophage colony stimulating factor (GM-CSF): one of a family of epithelial cell-derived cytokines in the preimplantation uterus
dc.typeJournal article
pubs.publication-statusPublished

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