Neuroinflammation: beneficial and detrimental effects after traumatic brain injury

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dc.contributor.authorFinnie, J.
dc.date.issued2013
dc.description.abstractTraumatic brain injury (TBI) is the major cause of death and severe disability in young adults and infants worldwide and many survivors also have mild to moderate neurological deficits which impair their lives. This review highlights the primary and secondary lesions constituting craniocerebral trauma and the main elements of neuroinflammation, one of the most important secondary events evolving after the initial traumatic insult. Neuroinflammation has dual and opposing roles in outcome after TBI, being both beneficial and harmful, its effects often differing between the acute and more delayed phases after injury. Since each patient with TBI has a unique and complex pattern of cerebral damage, developing pharmacological intervention strategies targeted at the multiple cellular and molecular events in the neuroinflammatory cascade is difficult. While there have been very few successful outcomes to date in human clinical trials of drugs developed to treat TBI in general, those that have been devised to modulate neuroinflammation are discussed.
dc.description.statementofresponsibilityJ. W. Finnie
dc.identifier.citationInflammopharmacology: experimental and clinical studies, 2013; 21(4):309-320
dc.identifier.doi10.1007/s10787-012-0164-2
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.orcidFinnie, J. [0000-0003-2277-1693]
dc.identifier.urihttp://hdl.handle.net/2440/79886
dc.language.isoen
dc.publisherKluwer Academic Publ
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1007/s10787-012-0164-2
dc.subjectTraumatic brain injury
dc.subjectNeuroinflammation
dc.subjectPharmacotherapeutics
dc.titleNeuroinflammation: beneficial and detrimental effects after traumatic brain injury
dc.typeJournal article
pubs.publication-statusPublished

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