Modulation of dorsal premotor cortex differentially influences I‐wave excitability in primary motor cortex of young and older adults

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dc.contributor.authorLiao, W.
dc.contributor.authorOpie, G.M.
dc.contributor.authorZiemann, U.
dc.contributor.authorSemmler, J.G.
dc.date.issued2023
dc.descriptionFirst published: 16 May 2023
dc.description.abstractPrevious research using transcranial magnetic stimulation (TMS) has demonstrated weakened connectivity between dorsal premotor cortex (PMd) and motor cortex (M1) with age. While this alteration is probably mediated by changes in the communication between the two regions, the effect of age on the influence of PMd on specific indirect (I) wave circuits within M1 remains unclear. The present study therefore investigated the influence of PMd on early and late I-wave excitability inM1of young and older adults. Twenty-two young (mean±SD, 22.9±2.9 years) and 20 older (66.6 ± 4.2 years) adults participated in two experimental sessions involving either intermittent theta burst stimulation (iTBS) or sham stimulation over PMd. Changes within M1 following the intervention were assessed with motor-evoked potentials (MEPs) recorded from the right first dorsal interosseous muscle. We applied posterior–anterior (PA) and anterior–posterior (AP) current single-pulse TMS to assess corticospinal excitability (PA1mV; AP1mV; PA0.5mV, early; AP0.5mV, late), and paired-pulse TMS short intracortical facilitation for I-wave excitability (PA SICF, early; AP SICF, late). Although PMd iTBS potentiated PA1mV and AP1mV MEPs in both age groups (both P < 0.05), the time course of this effect was delayed for AP1mV in older adults (P = 0.001). Furthermore, while AP0.5mV, PA SICF and AP SICF were potentiated in both groups (all P < 0.05), potentiation of PA0.5mV was only apparent in young adults (P < 0.0001).While PMd influences early and late I-wave excitability in young adults, direct PMdmodulation of the early circuits is specifically reduced in older adults.
dc.description.statementofresponsibilityWei-Yeh Liao, George M. Opie, Ulf Ziemann, and John G. Semmler
dc.identifier.citationThe Journal of Physiology, 2023; 601(14):2959-2974
dc.identifier.doi10.1113/jp284204
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.orcidLiao, W. [0000-0002-8912-9796]
dc.identifier.orcidOpie, G.M. [0000-0001-7771-7569]
dc.identifier.orcidSemmler, J.G. [0000-0003-0260-8047]
dc.identifier.urihttps://hdl.handle.net/2440/138672
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101009
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/APP1139723
dc.rights© 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1113/jp284204
dc.subjectMuscles
dc.subjectMotor Cortex
dc.subjectHumans
dc.subjectElectromyography
dc.subjectEvoked Potentials, Motor
dc.subjectAged
dc.subjectTranscranial Magnetic Stimulation
dc.subjectYoung Adult
dc.subjectCortical Excitability
dc.titleModulation of dorsal premotor cortex differentially influences I‐wave excitability in primary motor cortex of young and older adults
dc.typeJournal article
pubs.publication-statusPublished

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