Standardization of the sheep as a suitable animal model for studying endoscopic sinus surgery
| dc.contributor.author | Shaw, C. | |
| dc.contributor.author | Cowin, A. | |
| dc.contributor.author | Wormald, P. | |
| dc.date.issued | 2001 | |
| dc.description.abstract | Ten sheep were used to establish a standardized model for the study of endoscopic sinus surgery. The sheep was selected as the most suitable animal after extensive investigation of all possible models. The sheep's nasal cavity and sinuses are orientated in a similar fashion to man's. However, to access the maxillary, ethmoid and frontal sinus, the sheep's middle turbinate needs to be removed. Consequently the effects of middle turbinectomy on the nasal respiratory epithelium and cilial function were studied. Baseline mucociliary transport rates and patterns over the middle turbinate were observed using carbon powder as an insoluble tracer medium. The obstructing middle turbinates were then resected endoscopically. Mucosa on the lateral aspect of the middle turbinate which was not in contact with any nasal packing was taken as a control for histological examination. Three weeks after the turbinectomy, the cilial function of the lateral nasal wall was compared to the baseline mucociliary function. The percentage of intact ciliated mucosa of lateral nasal wall after turbinectomy was compared to the control. The turbinectomy did not significantly alter cilial function or respiratory epithelium. We conclude that the sheep is a suitable model for studying the healing process after endoscopic surgery. | |
| dc.description.statementofresponsibility | Chi-Kee Leslie Shaw, Allison Cowin and Peter-John Wormald | |
| dc.identifier.citation | Australian Journal of Otolaryngology, 2001; 4(1):23-26 | |
| dc.identifier.issn | 1037-2105 | |
| dc.identifier.orcid | Cowin, A. [0000-0003-2885-2080] | |
| dc.identifier.orcid | Wormald, P. [0000-0001-7753-7277] | |
| dc.identifier.uri | http://hdl.handle.net/2440/10325 | |
| dc.language.iso | en | |
| dc.publisher | Australian Society of Otolaryngology Head & Neck Surgery Ltd | |
| dc.title | Standardization of the sheep as a suitable animal model for studying endoscopic sinus surgery | |
| dc.type | Journal article | |
| pubs.publication-status | Published |