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Mapping multiple QTL for birth weight in cattle Using a mixed model approach

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dc.contributor.authorEsmailizadeh Koshkoih, A.
dc.contributor.authorPitchford, W.
dc.contributor.authorBottema, C.
dc.contributor.authorVerbyla, A.
dc.contributor.authorGilmour, A.
dc.contributor.conferenceWorld Congress on Genetics Applied to Livestock Production (8th : 2006 : Belo Horizonte, Brasil)
dc.date.issued2006
dc.description.abstractA mixed model approach was developed, allowing for the rapid detection of multiple QTL across the complete genome in half sib designs. The method fits all the markers simultaneously as independent random effects with common variance within linkage groups nested within sires. For the linkage groups with significant marker variance a QTL profile is predicted as a weighted function of the marker BLUP for each marker position and used to identify a putative QTL location. A putative QTL covariate was then calculated for that position from flanking markers and added to the model as a fixed effect nested within sires. If this did not explain all the marker variance, the process was repeated. The method was applied to analysis birth weight data from 356 animals representing three beef cattle half-sib families scored for 249 markers spread across 29 bovine autosomes. The results indicated significant evidence for QTL affecting birth weight on BTA1, 5, 13, 14, 21, 22 and 24.
dc.identifier.citationProceedings of the 8th World Congress on Genetics Applied to Livestock Production, 13-18 August, 2006: pp. [1-4]
dc.identifier.isbn8560088008
dc.identifier.orcidPitchford, W. [0000-0002-5213-3978]
dc.identifier.orcidBottema, C. [0000-0001-6245-0099]
dc.identifier.urihttp://hdl.handle.net/2440/39473
dc.language.isoen
dc.publisherWorld Congress on Genetics Applied to Livestock Production
dc.publisher.placeBelo Horizonte, Brasil
dc.titleMapping multiple QTL for birth weight in cattle Using a mixed model approach
dc.typeConference paper
pubs.publication-statusPublished

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