Beyond the borderline: outcomes for inborn infants born at ≤500 grams
| dc.contributor.author | Keir, A. | |
| dc.contributor.author | McPhee, A. | |
| dc.contributor.author | Wilkinson, D. | |
| dc.date.issued | 2014 | |
| dc.description | Article first published online: 6 OCT 2013 | |
| dc.description.abstract | Aim: To report survival, morbidity and neurodevelopmental outcome in a cohort of extremely low birthweight infants. Methods: Retrospective cohort study of all inborn infants born alive with birthweights ≤500 g ≥22 weeks gestation at Women's and Children's Hospital, Adelaide, Australia, over a 6-year period (2005–2010). Outcome data including standardised medical and psychological assessments at 12 and 36 months corrected age were collated from follow-up. Results: A total of 36 eligible infants were born over the study period (mean gestational age (GA) 24.4 (range 22.0–30.0) weeks; birthweight 443 (330–500) grams). Twenty-six of the 36 (72%) infants were small for gestational age (SGA).Ten of the 36 infants received compassionate care and died in the delivery or operating room. Twenty-six of the 36 infants were admitted to the neonatal intensive care unit (NICU), of whom 12 (46%) died during their admission. At age 12 months corrected, 2/14 (14%) of survivors had none/minimal, 4/14 (29%) had mild and 8/14 (57%) had moderate/severe neurodevelopmental disability. Overall, the survival rate was 39%, and survival without neurodevelopmental disability was 6%. Only 1/10 appropriate-for-gestational-age (AGA) infants survived to discharge (and had severe disability), whereas 13/26 (50%) of all SGA infants in the study survived to discharge. Of all infants admitted to the NICU, 11/26 (42%) survived without severe neurodevelopmental disability at latest follow-up. Conclusions: There was a high risk of death or impairment in this cohort of infants. Survival was rare for AGA infants weighing ≤500 g at birth. Our study provides an evidence base to assist counselling and decision-making. | |
| dc.description.statementofresponsibility | Amy Keir, Andrew McPhee and Dominic Wilkinson | |
| dc.identifier.citation | Journal of Paediatrics and Child Health, 2014; 50(2):146-152 | |
| dc.identifier.doi | 10.1111/jpc.12414 | |
| dc.identifier.issn | 1034-4810 | |
| dc.identifier.issn | 1440-1754 | |
| dc.identifier.orcid | Keir, A. [0000-0003-1692-5676] | |
| dc.identifier.orcid | McPhee, A. [0000-0003-3820-5696] | |
| dc.identifier.uri | http://hdl.handle.net/2440/86612 | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.rights | © The Authors 2013 | |
| dc.source.uri | https://doi.org/10.1111/jpc.12414 | |
| dc.subject | Counselling; ethics; infant; outcomes research; premature | |
| dc.title | Beyond the borderline: outcomes for inborn infants born at ≤500 grams | |
| dc.title.alternative | Beyond the borderline: outcomes for inborn infants born at </-500 grams | |
| dc.type | Journal article | |
| pubs.publication-status | Published |