The effects of prenatal exposure to a 'junk food' diet on offspring food preferences and fat deposition can be mitigated by improved nutrition during lactation

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dc.contributor.authorGugusheff, J.
dc.contributor.authorVithayathil, M.
dc.contributor.authorOng, Z.
dc.contributor.authorMuhlhausler, B.
dc.date.issued2013
dc.description.abstractExposure to a maternal junk food (JF) diet in utero and during the suckling period has been demonstrated to increase the preference for palatable food and increase the susceptibility to diet-induced obesity in adult offspring. We aimed to determine whether the effects of prenatal exposure to JF could be ameliorated by cross-fostering offspring onto dams consuming a standard rodent chow during the suckling period. We report here that when all offspring were given free access to the JF diet for 7 weeks from 10 weeks of age, male offspring of control (C) or JF dams that were cross-fostered at birth onto JF dams (C-JF, JF-JF), exhibited higher fat (C-C: 12.3 ± 0.34 g/kg/day; C-JF: 14.7 ± 1.04 g/kg/day; JF-C: 11.5 ± 0.41 g/kg/day; JF-JF: 14.0 ± 0.44 g/kg/day; P < 0.05) and overall energy intake (C-C: 930.1 ± 18.56 kJ/kg/day; C-JF: 1029.0 ± 82.9 kJ/kg/day; JF-C: 878.3 ± 19.5 kJ/kg/day; JF-JF: 1003.4 ± 25.97 kJ/kg/day; P < 0.05) than offspring exposed to the JF diet only before birth (JF-C) or not at all (C-C). Female offspring suckled by JF dams, despite no differences in food intake, had increased fat mass as percentage of body weight (C-C: 19.9 ± 1.33%; C-JF: 22.8 ± 1.57%; JF-C: 17.4 ± 1.03%; JF-JF: 22.0 ± 1.0%; P < 0.05) after 3 weeks on the JF diet. No difference in fat mass was observed in male offspring. These findings suggest that the effects of prenatal exposure to a JF diet on food preferences in females and susceptibility to diet-induced obesity in males can be prevented by improved nutrition during the suckling period.
dc.description.statementofresponsibilityJ. R. Gugusheff, M. Vithayathil, Z. Y. Ong and B. S. Muhlhausler
dc.identifier.citationJournal of Developmental Origins of Health and Disease, 2013; 4(5):348-357
dc.identifier.doi10.1017/S2040174413000330
dc.identifier.issn2040-1744
dc.identifier.issn2040-1752
dc.identifier.orcidMuhlhausler, B. [0000-0002-9021-6790]
dc.identifier.urihttp://hdl.handle.net/2440/80531
dc.language.isoen
dc.publisherCambridge University Press
dc.rights© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013
dc.source.urihttps://doi.org/10.1017/s2040174413000330
dc.subjectcross-fostering
dc.subjectfood preferences
dc.subjectnutritional programming
dc.titleThe effects of prenatal exposure to a 'junk food' diet on offspring food preferences and fat deposition can be mitigated by improved nutrition during lactation
dc.typeJournal article
pubs.publication-statusPublished

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