Retinal microvascular damage and vasogenic edema produced by Clostridium perfringens type D epsilon toxin in rats
Date
2014
Authors
Finnie, J.
Manavis, J.
Casson, R.
Chidlow, G.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Veterinary Diagnostic Investigation, 2014; 26(3):470-472
Statement of Responsibility
John W. Finnie, Jim Manavis, Robert J. Casson, Glyn Chidlow
Conference Name
Abstract
When the brain is exposed to large circulating levels of Clostridium perfringens type D epsilon toxin (EXT), microvascular damage with resulting severe, generalized, vasogenic edema seems to be principally responsible for the ensuing acute, and frequently fatal, neurologic disorder. However, although the blood-retinal barrier resembles in many respects the blood-brain barrier, retinal changes in livestock with acute epsilon intoxication have not, to the authors' knowledge, been previously reported. In rats given an acute dose of ETX, retinal microvascular endothelial injury led to widespread vasogenic edema as assessed immunohistochemically by marked plasma albumin extravasation. As laboratory rodents are a good model of the domestic livestock disease produced by ETX, it is probable that the latter sustain some visual deficit when exposed to large doses of this potent neurotoxin.
School/Discipline
Dissertation Note
Provenance
Description
Published online before print April 16, 2014
Access Status
Rights
© 2014 The Author(s)