Proteoglycans: potential agents in mammographic density and the associated breast cancer risk

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dc.contributor.authorShawky, M.
dc.contributor.authorRicciardelli, C.
dc.contributor.authorLord, M.
dc.contributor.authorWhitelock, J.
dc.contributor.authorFerro, V.
dc.contributor.authorBritt, K.
dc.contributor.authorThompson, E.
dc.date.issued2015
dc.description.abstractAlthough increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.
dc.description.statementofresponsibilityMichael S. Shawky, Carmela Ricciardelli, Megan Lord, John Whitelock, Vito Ferro, Kara Britt, Erik W. Thompson
dc.identifier.citationJournal of Mammary Gland Biology and Neoplasia, 2015; 20(3-4):121-131
dc.identifier.doi10.1007/s10911-015-9346-z
dc.identifier.issn1083-3021
dc.identifier.issn1573-7039
dc.identifier.orcidRicciardelli, C. [0000-0001-7415-1854]
dc.identifier.urihttp://hdl.handle.net/2440/96937
dc.language.isoen
dc.publisherSpringer
dc.rights© Springer Science+Business Media New York 2015
dc.source.urihttps://doi.org/10.1007/s10911-015-9346-z
dc.subjectBreast cancer
dc.subjectExtracellular matrix
dc.subjectGlypican
dc.subjectHeparanase
dc.subjectMammographic density
dc.subjectPerlecan
dc.subjectProteoglycans
dc.subjectSyndecan
dc.subjectVersican
dc.titleProteoglycans: potential agents in mammographic density and the associated breast cancer risk
dc.typeJournal article
pubs.publication-statusPublished

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