Chronic stress - the key to parturition?

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dc.contributor.authorMcMillen, I.
dc.contributor.authorPhillips, I.
dc.contributor.authorRoss, J.
dc.contributor.authorRobinson, J.
dc.contributor.authorOwens, J.
dc.date.issued1995
dc.description.abstractIt is clear that the timing of parturition is dependent on a cascade of endocrine signals from an intact fetal hypothalamo-pituitary-adrenal axis. What is not known, however is the nature or source of the central neural stimulation which results in the stimulation of adrenocorticotrophic hormone (ACTH) synthesis and secretion in late gestation. The changes which occur in the synthesis and posttranslational processing of the ACTH precursor, proopiomelanocortin (POMC), in the fetal anterior pituitary before birth and the consequence of these changes for expression of the corticosteroidogenic enzymes in the fetal adrenal are described in this review. Evidence for the functional heterogeneity of corticotrophic cell types in the fetal sheep pituitary and the proposal that there is a maturational change in the populations of corticotrophic cells in late gestation are discussed. Finally, the development of cortisol negative feedback in the late gestation fetal hypothalamo-pituitary axis and the relevance of chronic stress to the timing of parturition are also dicussed.
dc.description.statementofresponsibilityIC McMillen, ID Phillips, JT Ross, JS Robinson and JA Owens
dc.identifier.citationReproduction, Fertility and Development, 1995; 7(3):499-507
dc.identifier.doi10.1071/RD9950499
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.orcidRoss, J. [0000-0001-7243-1051]
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]
dc.identifier.urihttp://hdl.handle.net/2440/11957
dc.language.isoen
dc.publisherC S I R O PUBLICATIONS
dc.rights© CSIRO 1995
dc.source.urihttps://doi.org/10.1071/rd9950499
dc.subjectHypothalamus, pituitary, adrenal, fetus, proopiomelanocortin, ACTH, cortisol, corticotrophin-releasing factor, arginine vasopressin, hypoglycaemia, corticotroph
dc.titleChronic stress - the key to parturition?
dc.typeJournal article
pubs.publication-statusPublished

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