1,2,3-triazoles in peptidomimetic chemistry

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dc.contributor.authorPedersen, D.
dc.contributor.authorAbell, A.
dc.date.issued2011
dc.description.abstractThe ability to synthesise small peptidomimetics that mimic the secondary structure of proteins is an ever expanding area of research directed at sourcing new medicinal agents and biological probes. A significant current challenge is to mimic protein epitopes under physiological conditions using small peptidomimetics that are easy to prepare. The copper- and ruthenium-catalysed Huisgen cycloaddition reactions provide such a general synthetic method, with the resulting 1,2,3-triazoles being good peptide bond mimics. The ability to prepare both 1,4- and 1,5-substituted 1,2,3-triazoles under these chemically benign conditions provides both “linear” and “bent” peptidomimetics. Examples of the use of 1,2,3-triazoles to define the geometry and properties of a peptidomimetic abound. This review highlights such successes but also describes a number of failures in order to guide and inspire future efforts of chemists in this area.
dc.description.statementofresponsibilityDaniel Sejer Pedersen and Andrew Abell
dc.identifier.citationEuropean Journal of Organic Chemistry, 2011; 2011(13):2399-2411
dc.identifier.doi10.1002/ejoc.201100157
dc.identifier.issn1434-193X
dc.identifier.issn1099-0690
dc.identifier.orcidAbell, A. [0000-0002-0604-2629]
dc.identifier.urihttp://hdl.handle.net/2440/66714
dc.language.isoen
dc.publisherWiley-V C H Verlag GMBH
dc.rightsCopyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.source.urihttps://doi.org/10.1002/ejoc.201100157
dc.subjectCycloaddition
dc.subjectClick chemistry
dc.subjectPeptidomimetics
dc.subjectStructural Biology
dc.subjectProtein folding
dc.title1,2,3-triazoles in peptidomimetic chemistry
dc.typeJournal article
pubs.publication-statusPublished

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