Should patients with systemic sclerosis-related pulmonary arterial hypertension be anticoagulated?

Simple item page
dc.contributor.authorNikpour, M.
dc.contributor.authorStevens, W.
dc.contributor.authorProudman, S.
dc.contributor.authorBuchbinder, R.
dc.contributor.authorPrior, D.
dc.contributor.authorZochling, J.
dc.contributor.authorWilliams, T.
dc.contributor.authorGabbay, E.
dc.contributor.authorNandurkar, H.
dc.date.issued2013
dc.description.abstractPulmonary arterial hypertension (PAH) is a major cause of mortality in scleroderma and despite ‘advanced’ therapies confers a median survival of less than 5 years. Anticoagulation in systemic sclerosis-related PAH (SSc-PAH) is currently one of the most contentious issues in the management of patients with connective tissue disease. While some studies have shown a survival benefit with warfarin therapy in this disease, others have not. Accordingly, a state of clinical equipoise exists in relation to anticoagulation in SSc-PAH. With an over fivefold reduction in mortality demonstrated in some observational studies, the issue of anticoagulation in SSc-PAH demands resolution through a well-designed randomised controlled trial.
dc.description.statementofresponsibilityM. Nikpour, W. Stevens, S. M. Proudman, R. Buchbinder, D. Prior, J. Zochling, T. Williams, E. Gabbay and H. Nandurkar
dc.identifier.citationInternal Medicine Journal, 2013; 43(5):599-603
dc.identifier.doi10.1111/imj.12111
dc.identifier.issn1444-0903
dc.identifier.issn1445-5994
dc.identifier.orcidProudman, S. [0000-0002-3046-9884]
dc.identifier.urihttp://hdl.handle.net/2440/78667
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.rights© 2013 The Authors
dc.source.urihttps://doi.org/10.1111/imj.12111
dc.subjectscleroderma
dc.subjectsystemic sclerosis
dc.subjectpulmonary arterial hypertension
dc.subjectanticoagulation
dc.subjectrandomised controlled trial
dc.titleShould patients with systemic sclerosis-related pulmonary arterial hypertension be anticoagulated?
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications