Functional optical coherence tomography of pigmented lesions

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dc.contributor.authorWessels, R.
dc.contributor.authorDe Bruin, D.
dc.contributor.authorRelyveld, G.
dc.contributor.authorFaber, D.
dc.contributor.authorVincent, A.
dc.contributor.authorSanders, J.
dc.contributor.authorVan Leeuwen, T.
dc.contributor.authorRuers, T.
dc.date.issued2015
dc.description.abstractBackground: Cutaneous melanomas are diagnosed worldwide in 231,130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (μoct ). Objective: We hypothesize that OCT images of nevi will differ qualitatively and quantitatively from melanomas. Methods: Forty lesions from 33 consecutive patients were imaged with OCT. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of μoct were extracted from 200 OCT images of pigmented lesions. Results: Morphologically, absence of the lower border of the lesion was characteristic for melanoma (P = 0.02). Also, the μoct was different between benign and malignant lesions (P = 0.02). There were no differences in epidermal layer thickness of benign lesions and melanoma. Conclusion: Although this preliminary study comprised a small number of patients, quantitative analysis of OCT images in pigmented skin lesions give valuable additional information about lesions characteristics. When using the attenuation coefficient, it might be possible to distinguish between benign lesions and melanomas.
dc.description.statementofresponsibilityR. Wessels, D.M. de Bruin, G.N. Relyveld, D.J. Faber, A.D. Vincent, J. Sanders, T.G. van Leeuwen, T.J.M. Ruers
dc.identifier.citationJournal of the European Academy of Dermatology and Venereology, 2015; 29(4):738-744
dc.identifier.doi10.1111/jdv.12673
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.orcidVincent, A. [0000-0002-6428-1070]
dc.identifier.urihttp://hdl.handle.net/2440/116120
dc.language.isoen
dc.publisherWiley
dc.rights© 2014 European Academy of Dermatology and Venereology
dc.source.urihttps://doi.org/10.1111/jdv.12673
dc.subjectOptical coherence tomography
dc.titleFunctional optical coherence tomography of pigmented lesions
dc.typeJournal article
pubs.publication-statusPublished

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