Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience

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dc.contributor.authorKeefe, D.
dc.contributor.authorLees, J.
dc.contributor.authorHorvath, N.
dc.date.issued2006
dc.descriptionThe original publication can be found at www.springerlink.com
dc.description.abstractGoals of work the aim of this paper was to review the initial use of Palifermin(rHu-KGF1) in a single institution, for the prevention of oral mucositis in high-dose chemotherapy and stem cell transplantation. Methods the case records of the first five patients treated with Palifermin at the Royal Adelaide Hospital Cancer Centre were reviewed, and incidence,severity and duration of the oral mucositis were recorded, as well as demographics and toxicities. Results two of the five patients developed grade 4 mucositis, and the remaining three patients developed grade 2 mucositis. Palifemin was well tolerated with only one patient developing a rash. Conclusions the severity of oral mucositis was less than would be expected in these patients without anti-mucositis therapy. Palifermin was well tolerated. Obviously this single institution report is from a very small cohort of patients, but it is encouraging for the ease of use of this drug in the future.
dc.description.statementofresponsibilityDorothy Keefe, Jude Lees and Noemi Horvath
dc.identifier.citationSupportive Care in Cancer, 2006; 14(6):580-582
dc.identifier.doi10.1007/s00520-006-0048-3
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.orcidKeefe, D. [0000-0001-9377-431X]
dc.identifier.urihttp://hdl.handle.net/2440/23014
dc.language.isoen
dc.publisherSpringer-Verlag
dc.source.urihttp://www.springerlink.com/content/y304033x06457626/
dc.subjectHumans
dc.subjectStomatitis
dc.subjectDrug Eruptions
dc.subjectBusulfan
dc.subjectPodophyllotoxin
dc.subjectMelphalan
dc.subjectCyclophosphamide
dc.subjectCarmustine
dc.subjectCytarabine
dc.subjectAntineoplastic Agents
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectTreatment Outcome
dc.subjectTransplantation Conditioning
dc.subjectCombined Modality Therapy
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectDrug Administration Schedule
dc.subjectSeverity of Illness Index
dc.subjectIncidence
dc.subjectPrimary Prevention
dc.subjectTime Factors
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectCancer Care Facilities
dc.subjectSouth Australia
dc.subjectFemale
dc.subjectMale
dc.subjectFibroblast Growth Factor 7
dc.titlePalifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience
dc.typeJournal article
pubs.publication-statusPublished

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