Bacterial adaptation strategies to host-derived fatty acids

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dc.contributor.authorKengmo Tchoupa, A.
dc.contributor.authorEijkelkamp, B.A.
dc.contributor.authorPeschel, A.
dc.date.issued2022
dc.description.abstractFatty acids (FAs) are potent antimicrobials which hold great promise as viable alternatives or complements to conventional antibiotics. Intriguingly, bacteria are well equipped to use environmental FAs as energy sources and/or building blocks for their membrane lipids. Furthermore, these microbes display a wide array of mechanisms to prevent or mitigate FA toxicity. In this review we discuss strategies that bacteria use to thrive despite extensive exposure to host-derived antimicrobial FAs. We also highlight the altered response of these FA-adapted bacteria to antibiotics. Given the ubiquitous nature of FAs in various host environments, deciphering bacterial adaptation strategies to FAs is of prime importance. This knowledge may pave the way for a rational design of FA-based combination therapies with antibiotics.
dc.description.statementofresponsibilityArnaud Kengmo Tchoupa, Bart A. Eijkelkamp, and Andreas Peschel
dc.identifier.citationTrends in Microbiology, 2022; 30(3):241-253
dc.identifier.doi10.1016/j.tim.2021.06.002
dc.identifier.issn0966-842X
dc.identifier.issn1878-4380
dc.identifier.orcidEijkelkamp, B.A. [0000-0003-0179-8977]
dc.identifier.urihttps://hdl.handle.net/2440/134574
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/arc/DP210100553
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1159752
dc.rights© 2021 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.tim.2021.06.002
dc.subjectAntimicrobial fatty acids; bacterial pathogens; host–microbe interactions; adaptation strategies; antimicrobial resistance
dc.titleBacterial adaptation strategies to host-derived fatty acids
dc.typeJournal article
pubs.publication-statusPublished

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