Candida auris susceptibility on surfaces coated with the antifungal drug caspofungin

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dc.contributor.authorLamont-Friedrich, S.J.
dc.contributor.authorKidd, S.E.
dc.contributor.authorGiles, C.
dc.contributor.authorGriesser, H.J.
dc.contributor.authorCoad, B.R.
dc.date.issued2022
dc.description.abstractCandida auris is known to survive for weeks on solid material surfaces. Its longevity contributes to medical device contamination and spread through healthcare facilities. We fabricated antifungal surface coatings by coating plastic and glass surfaces with a thin polymer layer to which the antifungal drug caspofungin was covalently conjugated. Caspofungin-susceptible and -resistant C. auris strains were inhibited on these surfaces by 98.7 and 81.1%, respectively. Cell viability studies showed that this inhibition was fungicidal. Our findings indicate that C. auris strains can be killed on contact when exposed to caspofungin that is reformulated as a covalently-bound surface layer.
dc.description.statementofresponsibilityStephanie J. Lamont-Friedrich, Sarah E. Kidd, Carla Giles, Hans J. Griesser and Bryan R. Coad
dc.identifier.citationMedical Mycology, 2022; 60(1)
dc.identifier.doi10.1093/mmy/myab075
dc.identifier.issn1369-3786
dc.identifier.issn1460-2709
dc.identifier.orcidKidd, S.E. [0000-0002-5957-4178]
dc.identifier.orcidCoad, B.R. [0000-0003-3297-3977]
dc.identifier.urihttps://hdl.handle.net/2440/133923
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.relation.granthttp://purl.org/au-research/grants/arc/DP150101674
dc.rights©The Author(s) 2021. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
dc.source.urihttps://doi.org/10.1093/mmy/myab075
dc.subjectCandida auris; mycoses; infection control; drug resistance; fungal susceptibility
dc.titleCandida auris susceptibility on surfaces coated with the antifungal drug caspofungin
dc.typeJournal article
pubs.publication-statusPublished

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