Nonlinear drift-diffusion model of gating in the fast Cl channel
| dc.contributor.author | Vaccaro, Samuel Robert | en |
| dc.contributor.school | School of Chemistry and Physics : Physics and Mathematical Physics | en |
| dc.date.issued | 2007 | en |
| dc.description.abstract | The dynamics of the open or closed state region of an ion channel may be described by a probability density p(x,t) which satisfies a Fokker-Planck equation. The closed state dwell-time distribution fc(t) derived from the Fokker-Planck equation with a nonlinear diffusion coefficient D(x)∝exp(−γx), γ>0 and a linear ramp potential Uc(x), is in good agreement with experimental data and it may be shown analytically that if γ is sufficiently large, fc(t)∝t−2−ν for intermediate times, where ν=Uc′∕γ≈−0.3 for a fast Cl channel. The solution of a master equation which approximates the Fokker-Planck equation exhibits an oscillation superimposed on the power law trend and can account for an empirical rate-amplitude correlation that applies to several ion channels. | en |
| dc.description.statementofresponsibility | S. R. Vaccaro | en |
| dc.identifier.citation | Physical Review E, 2007; 76(1):011923 | en |
| dc.identifier.doi | 10.1103/PhysRevE.76.011923 | en |
| dc.identifier.issn | 1539-3755 | en |
| dc.identifier.uri | http://hdl.handle.net/2440/44523 | |
| dc.language.iso | en | en |
| dc.publisher | American Physical Society | en |
| dc.rights | ©2007 American Physical Society | en |
| dc.title | Nonlinear drift-diffusion model of gating in the fast Cl channel | en |
| dc.type | Journal article | en |
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