Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen

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dc.contributor.authorStaunton, E.
dc.contributor.authorSmid, S.
dc.contributor.authorDent, J.
dc.contributor.authorBlackshaw, L.
dc.date.issued2000
dc.description.abstractActivation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABA(B) receptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. We aimed to determine first whether this effect of baclofen is maintained at high-level distention and second the role of splanchnic pathways in triggering TLESR. Micromanometric/pH studies in conscious ferrets showed that intragastric glucose infusion (25 ml) increased triggering of TLESR and reflux. Both were significantly reduced by baclofen (7 micromol/kg ip) (P < 0.05). When 40 ml of air was added to the glucose infusion, more TLESR occurred than with glucose alone (P < 0.01). These were also reduced by baclofen (P < 0.001). TLESR after glucose/air infusion were assessed before and after splanchnectomy (2-4, 9-11, and 23-25 days), which revealed no change. Baclofen inhibits TLESR after both low- and high-level gastric distention. Splanchnic pathways do not contribute to increased triggering of TLESR by high-level gastric distention.
dc.identifier.citationAmerican Journal of Physiology - Gastrointestinal and Liver Physiology, 2000; 279(1 42-1):G157-G162
dc.identifier.doi10.1152/ajpgi.2000.279.1.g157
dc.identifier.issn0193-1857
dc.identifier.issn1522-1547
dc.identifier.orcidSmid, S. [0000-0003-4192-7219]
dc.identifier.urihttp://hdl.handle.net/2440/9243
dc.language.isoen
dc.publisherAmer Physiological Soc
dc.source.urihttps://doi.org/10.1152/ajpgi.2000.279.1.g157
dc.subjectMuscle, Smooth
dc.subjectEsophagogastric Junction
dc.subjectSplanchnic Nerves
dc.subjectAnimals
dc.subjectFerrets
dc.subjectGastroesophageal Reflux
dc.subjectBaclofen
dc.subjectCapsaicin
dc.subjectGlucose
dc.subjectReceptors, GABA-B
dc.subjectMuscle Relaxants, Central
dc.subjectMuscle Denervation
dc.subjectEating
dc.subjectPressure
dc.subjectFemale
dc.titleTriggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen
dc.typeJournal article
pubs.publication-statusPublished

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