Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use
Date
2009
Authors
Liu, G.
Shi, Z.
Kuriger, T.
Hanton, L.
Simpson, J.
Moratti, S.
Robinson, B.
Athanasiadis, T.
Valentine, R.
Wormald, P.
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Journal Title
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Type:
Journal article
Citation
Macromolecular Symposia, 2009; 279(1):151-157
Statement of Responsibility
G. Liu, Z. Shi, T. Kuriger, L.R. Hanton, J. Simpson, S.C. Moratti, B.H. Robinson, T. Athanasiadis, R. Valentine, P.J. Wormald, S. Robinson
Conference Name
Abstract
<jats:title>Abstract</jats:title><jats:p>A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.</jats:p>
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Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim