Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

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dc.contributor.authorSmith, N.
dc.contributor.authorShirazi, S.
dc.contributor.authorCakouros, D.
dc.contributor.authorGronthos, S.
dc.date.issued2023
dc.description.abstractMany crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases.
dc.description.statementofresponsibilityNicholas Smith, Suzanna Shirazi, Dimitrios Cakouros, and Stan Gronthos
dc.identifier.citationInternational Journal of Molecular Sciences, 2023; 24(7):6499-6499
dc.identifier.doi10.3390/ijms24076499
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.orcidSmith, N. [0000-0003-0444-324X]
dc.identifier.orcidCakouros, D. [0000-0001-6136-0761]
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]
dc.identifier.urihttps://hdl.handle.net/2440/138071
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1141361
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2007554
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttps://doi.org/10.3390/ijms24076499
dc.subjectbone marrow stromal cells; mesenchymal stem cells; epigenetics; osteogenic; bone; skeleton; DNA methylation; histone methylation; histone acetylation
dc.subject.meshMesenchymal Stem Cells
dc.subject.meshCell Differentiation
dc.subject.meshDNA Methylation
dc.subject.meshEpigenesis, Genetic
dc.titleImpact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
dc.typeJournal article
pubs.publication-statusPublished

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