Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice

Simple item page
dc.contributor.authorHanifa, S.
dc.contributor.authorScott, H.
dc.contributor.authorCrewther, P.
dc.contributor.authorGuipponi, M.
dc.contributor.authorTan, J.
dc.date.issued2010
dc.description.abstractComplete deficiency of a member of the type II transmembrane serine protease family, tmprss1 (also known as hepsin), is associated with severe to profound hearing loss in mice and a gross enlargement of the tectorial membrane in the cochlea. Levels of thyroxine in these mice have been shown to be significantly lower when compared with wild-type controls. As thyroxine is critical for inner ear development, we delivered thyroxine to these mice during the prenatal or postnatal stage of development. Both the treatments could not ameliorate hearing loss or correct deformities in the tectorial membrane of these mutant mice, suggesting that a deficiency in tmprss1 affects thyroxine responsiveness in the inner ear in vivo.
dc.identifier.citationNeuroReport, 2010; 21(13):897-901
dc.identifier.doi10.1097/WNR.0b013e32833dbd2d
dc.identifier.issn0959-4965
dc.identifier.issn1473-558X
dc.identifier.orcidScott, H. [0000-0002-5813-631X]
dc.identifier.urihttp://hdl.handle.net/2440/62995
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rights© 2010 Lippincott Williams & Wilkins, Inc.
dc.source.urihttps://doi.org/10.1097/wnr.0b013e32833dbd2d
dc.subjectcochlea
dc.subjecthepsin
dc.subjecthypothyroidism
dc.subjectresistance to thyroid hormones
dc.subjecttectorial membrane
dc.subjectthyroid hormones
dc.subjecttransmembrane serine protease.
dc.titleThyroxine treatments do not correct inner ear defects in tmprss1 mutant mice
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications