A biomimetic synthetic approach to the frondosins
Date
2016
Authors
Kuan, K.
Hirschvogel, A.
George, J.
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Journal article
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Australian Journal of Chemistry, 2016; 69(12):1420-1423
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Kevin K. W. Kuan, Aylin M. C. Hirschvogel and Jonathan H. George
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Abstract
The frondosins are a family of five marine sponge-derived meroterpenoids. We propose that the 6-7 ring system common to each of the frondosins is biosynthesized via ring expansion of a 6–6 ring system. Compelling evidence in favour of this proposal was obtained in the form of a biomimetic synthesis of the frondosin 6–7 ring system, which features a highly stereo- and regio-selective ring expansion cascade reaction as the key step.
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Journal compilation © CSIRO 2016