Factors influencing thigh muscle volume change with cycling exercises in acute spinal cord injury - a secondary analysis of a randomized controlled trial.

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dc.contributor.authorPanisset, M.G.
dc.contributor.authorEl-Ansary, D.
dc.contributor.authorDunlop, S.A.
dc.contributor.authorMarshall, R.
dc.contributor.authorClark, J.
dc.contributor.authorChurilov, L.
dc.contributor.authorGalea, M.P.
dc.date.issued2022
dc.descriptionPublished online: 24 Sep 2020
dc.description.abstractObjective: To conduct a per-protocol analysis on thigh muscle volume outcomes from the Spinal Cord Injury and Physical Activity (SCIPA) Switch-On Trial. Design: Secondary analysis from an assessor-blind randomized, controlled trial. Setting: Four acute/sub-acute hospitals in Australia and New Zealand. Participants: 24 adults (1 female) within four weeks of motor complete or incomplete spinal cord injury (SCI) Intervention: Functional electrical stimulation-assisted cycling (FESC) or passive cycling (PC) 4x/week for 12 weeks. Outcome Measures: Whole thigh and muscle group volumes calculated from manually segmented MR images. Results: 19/24 participants completed ≥ twelve weeks of the intervention. Five participants experienced hypertrophy (4 FESC; 1 PC) and eight attenuation of atrophy (<20% volume loss) (3 FESC; 5 PC) in thigh muscle volume. Six participants were non-responders, exhibiting atrophy >20% (3 FESC; 3 PC). Mean (SD) change for FESC was -2.3% (25.3%) and PC was -14.0% (12.3%). After controlling for baseline muscle volumes, a strong significant correlation was found between mean weekly exercise frequency and quadriceps and hamstring volumes (r=6.25, P=0.006), regardless of mode. Average watts was highly correlated to quadriceps volumes only (r=5.92, P=0.01), while total number of sessions was strongly correlated with hamstring volumes only (r=5.91, P=0.01). Conclusion: This per-protocol analysis of FESC and PC early after SCI reports a partial response in 42% and a beneficial response in 25% of patients who completed 12 weeks intervention, regardless of mode. Strong correlations show a dose-response according to exercise frequency. Characteristics of non-responders are discussed to inform clinical decision-making.
dc.description.statementofresponsibilityMaya G. Panisset, Doa El-Ansary, Sarah Alison Dunlop, Ruth Marshall, Jillian Clark, Leonid Churilov and Mary P. Galea
dc.identifier.citationJournal of Spinal Cord Medicine, 2022; 45(4):510-521
dc.identifier.doi10.1080/10790268.2020.1815480
dc.identifier.issn1079-0268
dc.identifier.issn2045-7723
dc.identifier.orcidMarshall, R. [0000-0003-1183-3502]
dc.identifier.urihttp://hdl.handle.net/2440/129177
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1042653
dc.rights© The Academy of Spinal Cord Injury Professionals, Inc. 2020
dc.source.urihttps://doi.org/10.1080/10790268.2020.1815480
dc.subjectAtrophy
dc.subjectCycling
dc.subjectFunctional electrical stimulation
dc.subjectMuscle volumes
dc.subjectSpinal cord injury
dc.titleFactors influencing thigh muscle volume change with cycling exercises in acute spinal cord injury - a secondary analysis of a randomized controlled trial.
dc.typeJournal article
pubs.publication-statusPublished

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