Actual endoscopic versus predicted surgical mortality for treatment of advanced mucosal neoplasia of the colon

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dc.contributor.authorAhlenstiel, G.
dc.contributor.authorHourigan, L.
dc.contributor.authorBrown, G.
dc.contributor.authorZanati, S.
dc.contributor.authorWilliams, S.
dc.contributor.authorSingh, R.
dc.contributor.authorMoss, A.
dc.contributor.authorSonson, R.
dc.contributor.authorBourke, M.
dc.contributor.authorAustralian Colonic Endoscopic Mucosal Resection (ACE) Study Group,
dc.date.issued2014
dc.description.abstractBackground: EMR of advanced mucosal neoplasia (AMN) (ie, sessile or laterally spreading lesions of R20 mm) of the colon has become an increasingly popular alternative to surgical resection. However, data regarding safety and mortality of EMR in comparison to surgery are limited. Objective: To compare actual endoscopic with predicted surgical mortality. Design: Prospective, observational, multicenter cohort study. Setting: Academic, high-volume, tertiary-care referral center. Patients: Consecutive patients referred for EMR. Intervention: EMR. Main Outcome Measurements: To predict hypothetical surgical mortality, the Association of Coloproctology of Great Britain and Ireland score, composed of physiological and surgical components, was calculated for each patient. Predicted surgical mortality was then compared with actual outcomes of EMR. The results were validated by an unselected subcohort by using the Colorectal Physiologic and Operative Severity Score for Enumeration of Mortality and Morbidity. Results: Among 1050 patients with AMN treated by EMR, including patients with a predicted mortality rate of greater than 5% (13.8% of cohort), no deaths occurred within 30 days after the procedure. The predicted surgical mortality rate was 3.3% with the Association of Coloproctology of Great Britain and Ireland score (P!.0001). This suggests a significant advantage of EMR over surgery. The results were validated by using the Colorectal Physiologic and Operative Severity Score for Enumeration of Mortality and Morbidity in 390 patients predicting a surgical mortality rate of 3.2% (P Z .0003). Limitations: Nonrandomized study. Conclusion: In this large multicenter study of EMR for colonic AMN, the predicted surgical mortality rate was significantly higher than the actual endoscopic mortality rate. Given that endoscopic therapy is less morbid and less expensive than surgery and can be performed as an outpatient treatment, it should be considered as the first line of treatment for most patients with these lesions. (Gastrointest Endosc 2014;80:668-76.)
dc.description.statementofresponsibilityGolo Ahlenstiel, Luke F. Hourigan, Gregor Brown, Simon Zanati, Stephen J. Williams, Rajvinder Singh, Alan Moss, Rebecca Sonson, Michael J. Bourke, The Australian Colonic Endoscopic Mucosal Resection, ACE, Study Group
dc.identifier.citationGastrointestinal Endoscopy, 2014; 80(4):668-676
dc.identifier.doi10.1016/j.gie.2014.04.015
dc.identifier.issn0016-5107
dc.identifier.issn1097-6779
dc.identifier.orcidSingh, R. [0000-0001-9116-6054]
dc.identifier.urihttp://hdl.handle.net/2440/102938
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright © 2014 by the American Society for Gastrointestinal Endoscopy
dc.source.urihttps://doi.org/10.1016/j.gie.2014.04.015
dc.subjectAustralian Colonic Endoscopic Mucosal Resection (ACE) Study Group
dc.subjectIntestinal Mucosa
dc.subjectHumans
dc.subjectColonic Neoplasms
dc.subjectNeoplasm Invasiveness
dc.subjectColonoscopy
dc.subjectNeoplasm Staging
dc.subjectDisease-Free Survival
dc.subjectCause of Death
dc.subjectRisk Assessment
dc.subjectSurvival Analysis
dc.subjectCohort Studies
dc.subjectProspective Studies
dc.subjectPredictive Value of Tests
dc.subjectEducation, Medical, Continuing
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.titleActual endoscopic versus predicted surgical mortality for treatment of advanced mucosal neoplasia of the colon
dc.typeJournal article
pubs.publication-statusPublished

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