The most common vices of men can damage fertility and the health of the next generation

Simple item page
dc.contributor.authorFullston, T.
dc.contributor.authorMc Pherson, N.O.
dc.contributor.authorZander, D.
dc.contributor.authorLane, M.
dc.date.issued2017
dc.description.abstractAnimal and human studies demonstrate that acquired paternal traits can impair both a male’s fertility and the health of his offspring, including advanced age, smoking, stress, trauma, under-nutrition, infection, toxin exposure, and obesity. Many of these factors lead to similar changes to neurological, behavioural, and/or metabolic functioning in offspring. The molecular mechanisms that both respond to the paternal environment and act to transmit traits to offspring are beginning to emerge. This review focuses on three vices of men (alcohol consumption, overweight/obesity, and tobacco smoking) that damage fertility and pose risks to offspring health. These vices are not only the three most prevalent but are also leading risk factors for death and disability adjusted life years (DALYs) worldwide. Moreover, given that these vices are predominantly self-inflicted, interventions aimed at mitigating their consequences are readily identified.
dc.description.statementofresponsibilityTod Fullston, Nicole O McPherson, Deirdre Zander-Fox and Michelle Lane
dc.identifier.citationJournal of Endocrinology, 2017; 234(2):F1-F6
dc.identifier.doi10.1530/joe-16-0382
dc.identifier.issn0022-0795
dc.identifier.issn1479-6805
dc.identifier.orcidFullston, T. [0000-0003-1314-3038]
dc.identifier.orcidMc Pherson, N.O. [0000-0002-3492-9403]
dc.identifier.urihttp://hdl.handle.net/2440/107445
dc.language.isoen
dc.publisherBioscientifica
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1088964
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1042089
dc.rights© 2017 Society for Endocrinology. Published by Bioscientifica Ltd.
dc.source.urihttps://doi.org/10.1530/joe-16-0382
dc.subjectMale fertility; paternal programming; sperm epigenetics; environmental exposure
dc.titleThe most common vices of men can damage fertility and the health of the next generation
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Obstetrics and Gynaecology publications