Transport of immuno-targeted nanoparticles in 3D tumour spheroids and in vivo models /
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(Published version)
Date
2014
Authors
Liu, Tianqing,
Editors
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Journal Title
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Volume Title
Type:
thesis
Citation
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Abstract
Immuno-targeted nanomedicines, i.e. nanomaterials conjugated with biological entities targeted to specific biomarkers, are recognized as the next generation nanomedicines for cancer detection and treatment and are being actively developed worldwide. However, there is a lack of understanding of the transport, binding and clearance of these immuno-targeted agents in solid tumour and metastatic lesions. This knowledge gap limits successful clinical implementation of these immuno-targeted nanomedicines. This thesis aims to elucidate some of the key parameters and processes regulating the penetration of immuno-targeted nanomedicines in both interstitial tumour and lymphatic tissues. This fundamental understanding will facilitate the design of more efficient diagnostic and therapeutic nanomedicines.
School/Discipline
Ian Wark Research Institute.
Ian Wark Research Institute.
Ian Wark Research Institute.
Dissertation Note
Thesis (PhD(Applied Science: Minerals and Materials))--University of South Australia, 2014.
Provenance
Copyright 2014 Tianqing Liu.
Description
1 ethesis (187 pages) :
illustrations (some colour)
Includes bibliographical references.
illustrations (some colour)
Includes bibliographical references.
Access Status
506 0#$fstar $2Unrestricted online access