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Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

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dc.contributor.authorAppelhans, D.
dc.contributor.authorKlajnert Maculewicz, B.
dc.contributor.authorJanaszewska, A.
dc.contributor.authorLazniewska, J.
dc.contributor.authorVoit, B.
dc.date.issued2015
dc.description.abstractIn this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with various (bio)molecules are elucidated with various examples. A special role of the individual sugar units attached to the dendritic scaffolds and their density is identified, which govern ionic and H-bond interactions, and biological targeting, but to a large extent are also responsible for the significantly reduced toxicity of the dendritic glycopolymers compared to their polyamine scaffolds. Thus, the application of dendritic glycopolymers in drug delivery systems for gene transfection but also as therapeutics in neurodegenerative diseases has great promise.
dc.identifier.citationChemical Society Reviews, 2015; 44(12):3968-3996
dc.identifier.doi10.1039/c4cs00339j
dc.identifier.issn0306-0012
dc.identifier.issn1460-4744
dc.identifier.urihttps://hdl.handle.net/11541.2/127576
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.rightsCopyright 2015 Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. (https://creativecommons.org/licenses/by-nc/3.0/)
dc.source.urihttp://dx.doi.org/10.1039/c4cs00339j
dc.subjectdendritic glycopolymers
dc.subjectpolyamine scaffolds
dc.subjectgene transfection
dc.subjectbiomedicine
dc.subjectbiological targeting
dc.subjectdrug delivery
dc.subjecttherapeutics
dc.titleDendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916141697201831

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