The effect of cisapride on oral and intravenous glucose tolerance in normal subjects

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dc.contributor.authorWishart, J.
dc.contributor.authorHorowitz, M.
dc.contributor.authorCampbell, J.
dc.contributor.authorJones, K.
dc.date.issued1997
dc.description.abstractCisapride is used widely for the treatment of diabetic gastroparesis. There is some evidence that cisapride may influence insulin secretion. The aim of this study was to evaluate the effect of cisapride on plasma concentrations of glucose, insulin and C-peptide in response to oral and intravenous glucose loads. Twelve normal subjects took cisapride and placebo, each for 10 days using a randomized, double-blind, crossover design. In each treatment phase, the plasma glucose, insulin and C-peptide response to intravenous (0.5 g/kg) and oral (75 g) glucose loads was evaluated on separate days. Gastric emptying of the oral glucose load was also measured. After the intravenous glucose load, plasma concentrations of C-peptide were higher (P< 0.01) on cisapride when compared with placebo (e.g. peak C-peptide 2.08+/-0.25 nmol/L vs 1.78+/-0.22 nmol/L, P< 0.01) while there was no significant difference in plasma glucose or insulin. Cisapride had no effect on the rate of gastric emptying of the oral glucose load. Mean plasma concentrations of insulin and C-peptide were higher after oral glucose on cisapride than placebo, but these differences were not significantly different. These observations indicate that cisapride may increase glucose-stimulated insulin secretion.
dc.description.statementofresponsibilityWishart, Judith M Horowitz, Michael; Campbell, Joanne; Jones, Karen L
dc.identifier.citationJournal of Gastroenterology and Hepatology (Australia), 1997; 12(12):795-800
dc.identifier.doi10.1111/j.1440-1746.1997.tb00374.x
dc.identifier.issn0815-9319
dc.identifier.issn1440-1746
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.urihttp://hdl.handle.net/2440/8973
dc.language.isoen
dc.publisherBLACKWELL SCIENCE
dc.source.urihttps://doi.org/10.1111/j.1440-1746.1997.tb00374.x
dc.subjectHumans
dc.subjectGlucose Intolerance
dc.subjectCisapride
dc.subjectPiperidines
dc.subjectInsulin
dc.subjectC-Peptide
dc.subjectGlucose
dc.subjectGastrointestinal Agents
dc.subjectGlucose Tolerance Test
dc.subjectAdministration, Oral
dc.subjectInjections, Intravenous
dc.subjectOsmolar Concentration
dc.subjectReference Values
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleThe effect of cisapride on oral and intravenous glucose tolerance in normal subjects
dc.typeJournal article
pubs.publication-statusPublished

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