Current studentsExisting staffContact us
 

Genetic variants linked to education predict longevity

Simple item page
dc.contributor.authorMarioni, R.E.
dc.contributor.authorRitchie, S.J.
dc.contributor.authorJoshi, P.K.
dc.contributor.authorHagenaars, S.P.
dc.contributor.authorHypponen, E.
dc.contributor.authorBenjamin, D.J.
dc.date.issued2016
dc.descriptionData source: Supporting information, https://doi.org/10.1073/pnas.1605334113
dc.description.abstractEducational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n deaths = 79,702) and ∼2.4% lower risk for fathers (total n deaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2016; 113(47):13366-13371
dc.identifier.doi10.1073/pnas.1605334113
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/11541.2/139721
dc.language.isoen
dc.publisherNational Academy of Sciences
dc.rightsCopyright 2016 National Academy of Sciences Access Condition Notes: Freely available online through the PNAS open access option
dc.source.urihttps://www.pnas.org/doi/10.1073/pnas.1605334113
dc.subjecteducation
dc.subjectgenetics
dc.subjectlongevity
dc.subjectpolygenic score
dc.subjectprediction
dc.titleGenetic variants linked to education predict longevity
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12183419300001831 13183419290001831 13366.full.pdf
ror.mmsid9916284707901831

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
9916284707901831_12183419300001831_13366.full.pdf
Size:
665.3 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections