In vitro osteosarcoma biosensing using THz time domain spectroscopy
Date
2004
Authors
Ferguson, B.
Liu, H.
Hay, S.
Findlay, D.
Zhang, X.
Abbott, D.
Editors
Faraone, L.
Vardan, V.K.
Vardan, V.K.
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Conference paper
Citation
BioMEMS and nanotechnology : 10-12 December 2003, Perth, Australia / Dan V. Nicolau, Uwe R. Muller, John M. Dell (eds.), pp. 304-316
Statement of Responsibility
Bradley S. Ferguson, Haibo Liu, Shelley Hay, David Findlay, Xi-Cheng Zhang, and Derek Abbott
Conference Name
Microelectronics, MEMS, and Nanotechnology 2003 (10 December 2003 : Perth, Australia)
Abstract
Terahertz time domain spectroscopy (THz-TDS) has a wide range ofapplications from semiconductor diagnostics to biosensing. Recentattention has focused on bio-applications and several groups havenoted the ability of THz-TDS to differentiate basal cell carcinomatissue from healthy dermal tissue ex vivo.The contrast mechanism is unclear but has been attributed toincreased interstitial water in cancerous tissue. In this work weinvestigate the THz response of human osteosarcoma cells andnormal human bone cells grown in culture to isolate the cells'responses from other effects. A classification algorithms basedon a frequency selection by genetic algorithm is used to attemptto differentiate between the cell types based on the THz spectra.Encouraging preliminary results have been obtained.
School/Discipline
Dissertation Note
Provenance
Description
© 2004 COPYRIGHT SPIE--The International Society for Optical Engineering