Asciminib for chronic myeloid leukaemia: Next questions
Date
2022
Authors
Shanmuganathan, N.
Hughes, T.P.
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Journal article
Citation
British Journal of Haematology, 2022; 199(3):322-331
Statement of Responsibility
Naranie Shanmuganathan, Timothy P. Hughes
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Abstract
Recent approval of asciminib, a novel “specifically targeting the ABL myristoyl pocket” (STAMP) BCR- ABL1 inhibitor, for the treatment of chronic myeloid leukae-mia (CML) patients who have either failed ≥2 lines of therapy or have the T315I muta-tion, has provided clinicians with a wider selection of potentially effective treatment options. Asciminib has the attractive twin attributes of high potency directed against BCR- ABL1 and good tolerability based on its limited off-target effects. However, it is unclear exactly where asciminib will be positioned amongst the other available tyrosine kinase inhibitors (TKIs), especially ponatinib which is also available for the same indications. There are many questions yet to be answered with regard to the optimal use of asciminib which include its role in the first- and second-line settings, combination therapy with other TKIs, and effectiveness in advanced phase CML. In this review, we discuss the available data on asciminib while exploring a number of clinical trials in progress. Finally, we provide our opinion based on the current data about where asciminib is most likely to be the optimal choice, which will hopefully assist clinicians with therapy selection.
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First published: 21 June 2022
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© 2022 British Society for Haematology and John Wiley & Sons Ltd.