Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease

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dc.contributor.authorZaman, S.
dc.contributor.authorCampaner, P.
dc.contributor.authorAbell, A.
dc.date.issued2006
dc.descriptionCopyright © 2006 Elsevier Ltd All rights reserved.
dc.description.abstractA versatile synthesis of hydroxylated and epoxy 1-azepin 2-ones substituted at N1, C-3 and C-4 or C-7 has been developed. The sequence involves ring-closing metathesis of an amino acid derived diene amide, followed by either epoxidation or dihydroxylation, of the resulting alkene. Assay of the product epoxides (10, 18, 25) and diols (9a, 17, 24) against HIV protease reveals micromolar inhibition.
dc.description.statementofresponsibilityShazia Zaman, Pietro Campaner and Andrew D. Abell
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description
dc.identifier.citationBioorganic and Medicinal Chemistry, 2006; 14(24):8323-8331
dc.identifier.doi10.1016/j.bmc.2006.09.009
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.orcidAbell, A. [0000-0002-0604-2629]
dc.identifier.urihttp://hdl.handle.net/2440/34879
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.source.urihttps://doi.org/10.1016/j.bmc.2006.09.009
dc.subjectRing-closing metathesis
dc.subjectLactams
dc.subjectDiol
dc.subjectHIV protease
dc.titleSynthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease
dc.typeJournal article
pubs.publication-statusPublished

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