Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in thoroughbred foals

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dc.contributor.authorJenvey, C.
dc.contributor.authorCaraguel, C.
dc.contributor.authorHowarth, G.
dc.contributor.authorRiley, C.
dc.date.issued2012
dc.description.abstractREASONS FOR PERFORMING THE STUDY: Prior to the start of endogenous production of immunoglobulins (Igs), absorption of maternal Igs is important to protect against pathogens in the early neonatal period. It is possible that mare-or foal-associated factorsmay influence neonatal IgA concentrations. OBJECTIVES: The temporal relationships among serum and milk IgA concentrations in Thoroughbred mare–foal pairs were explored to determine if periparturient mare- and foal-associated factors contribute to the prediction of foal serum IgA concentrations. METHODS: Blood and milk samples as well as complete veterinary records, were collected for 84 Thoroughbred mare–foal pairs fromone month before to 2 months after parturition. Sampleswere tested using enzyme-linked immunosorbent assay (ELISA) for concentrations of IgA. Pairwise correlation coefficients were estimated (P<0.01) and simple linear regression used to investigate unconditional associations between mare IgA levels, mare and foal risk factors and foal serum IgA concentration at 12 h. Backwards, stepwise elimination of nonsignificant factors was used to create a final model. RESULTS: There were significant temporal relationships among mare serum IgA and among colostrum and milk IgA concentrations within mares (P0.01). Mare serum IgA concentrations up to one month before parturitionwere associated with foal serum IgA concentrations at all time points and with colostrum and milk IgA concentrations. Mare serum IgA at -28 days and parity were associated with foal serum IgA concentration at 12 h (P0.001). CONCLUSIONS: Mare serum IgA concentrations up to 28 days before parturition, together with mare parity, are indicative of neonatal foal serum IgA concentrations. POTENTIAL RELEVANCE: Mare serum and colostrum IgA concentrations may be useful peripartum predictors of neonatal mucosal immune status, enabling earlier intervention to prevent the consequences of mucosal infections.
dc.description.statementofresponsibilityC. Jenvey, C. Caraguel, G.B. Howarth and C.B. Riley
dc.identifier.citationEquine Veterinary Journal, 2012; 44(SUPPL. 43):73-77
dc.identifier.doi10.1111/j.2042-3306.2012.00648.x
dc.identifier.issn0425-1644
dc.identifier.issn2042-3306
dc.identifier.orcidCaraguel, C. [0000-0003-0019-4813]
dc.identifier.orcidHowarth, G. [0000-0001-6979-6084]
dc.identifier.urihttp://hdl.handle.net/2440/75007
dc.language.isoen
dc.publisherEquine Veterinary Journal Ltd
dc.rights© 2012 EVJ Ltd
dc.source.urihttps://doi.org/10.1111/j.2042-3306.2012.00648.x
dc.subjecthorse
dc.subjectfoal
dc.subjectpredictors
dc.subjectmaternal
dc.subjectimmunoglobulin
dc.subjectIgA
dc.titleIdentification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in thoroughbred foals
dc.typeJournal article
pubs.publication-statusPublished

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