Translating the biology of β common receptor-engaging cytokines into clinical medicine

Simple item page
dc.contributor.authorPant, H.
dc.contributor.authorHercus, T.R.
dc.contributor.authorTumes, D.J.
dc.contributor.authorYip, K.H.
dc.contributor.authorParker, M.W.
dc.contributor.authorOwczarek, C.M.
dc.contributor.authorLopez, A.F.
dc.contributor.authorHuston, D.P.
dc.date.issued2022
dc.description.abstractThe family of cytokines that comprises IL-3, IL-5, and GM-CSF was discovered over 30 years ago, and their biological activities and resulting impact in clinical medicine has continued to expand ever since. Originally identified as bone marrow growth factors capable of acting on hemopoietic progenitor cells to induce their proliferation and differentiation into mature blood cells, these cytokines are also recognized as key mediators of inflammation and the pathobiology of diverse immunologic diseases. This increased understanding of the functional repertoire of IL-3, IL-5, and GM-CSF has led to an explosion of interest in modulating their functions for clinical management. Key to the successful clinical translation of this knowledge is the recognition that these cytokines act by engaging distinct dimeric receptors and that they share a common signaling subunit called β-common or βc. The structural determination of how IL-3, IL-5, and GM-CSF interact with their receptors and linking this to their differential biological functions on effector cells has unveiled new paradigms of cell signaling. This knowledge has paved the way for novel mAbs and other molecules as selective or pan inhibitors for use in different clinical settings.
dc.description.statementofresponsibilityHarshita Pant, Timothy R. Hercus, Damon J. Tumes, Kwok Ho Yip, Michael W. Parker, Catherine M. Owczarek, Angel F. Lopez, and David P. Huston
dc.identifier.citationJournal of Allergy and Clinical Immunology, 2022; 151(2):324-344
dc.identifier.doi10.1016/j.jaci.2022.09.030
dc.identifier.issn0091-6749
dc.identifier.issn1097-6825
dc.identifier.orcidTumes, D.J. [0000-0001-5709-857X]
dc.identifier.orcidLopez, A.F. [0000-0001-7430-0135]
dc.identifier.urihttps://hdl.handle.net/2440/137667
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2004288
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1071897
dc.relation.granthttp://purl.org/au-research/grants/arc/DP220101788
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1117183
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1194263
dc.rights© 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
dc.source.urihttps://doi.org/10.1016/j.jaci.2022.09.030
dc.subjectCOPD
dc.subjectGM-CSF
dc.subjectIL-3
dc.subjectIL-5
dc.subjectasthma
dc.subjectautoimmune
dc.subjectbasophils
dc.subjectcancer
dc.subjectchronic inflammation
dc.subjecteosinophils
dc.subjectnasal polyps
dc.subjectβ-common receptor cytokines
dc.subject.meshEosinophils
dc.subject.meshHumans
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor
dc.subject.meshInterleukin-3
dc.subject.meshInterleukin-5
dc.subject.meshCytokines
dc.subject.meshBiology
dc.subject.meshClinical Medicine
dc.titleTranslating the biology of β common receptor-engaging cytokines into clinical medicine
dc.title.alternativeTranslating the biology of B common receptor-engaging cytokines into clinical medicine
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications