If good things come from above, do bad things come from below?

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dc.contributor.authorFindlay, D.
dc.date.issued2010
dc.description.abstractFactors in the synovial fluid that maintain healthy articular cartilage, such as hyaluronic acid and lubricin, come from above. Is it possible that factors which lead to the destruction of cartilage come from below in the subchondral bone? The recent acquisition of tools to probe early events in osteoarthritis is shedding new light on possible contributions from this compartment on the initiation and progression of the disease. Tanamas and co-workers now provide evidence that bone marrow lesions in the subchondral bone are predictive, both of loss of cartilage and of formation of subchondral cysts. These data provoke questions about the nature and role of bone marrow lesions.
dc.description.statementofresponsibilityDavid M. Findlay
dc.identifier.citationArthritis Research & Therapy, 2010; 12(3):119-1-119-2
dc.identifier.doi10.1186/ar3007
dc.identifier.issn1478-6362
dc.identifier.issn1478-6362
dc.identifier.urihttp://hdl.handle.net/2440/61068
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.rights© 2010 BioMed Central Ltd
dc.source.urihttps://doi.org/10.1186/ar3007
dc.subjectCartilage, Articular
dc.subjectChondrocytes
dc.subjectHumans
dc.subjectBone Cysts
dc.subjectOsteoarthritis, Knee
dc.subjectDisease Progression
dc.subjectGlycoproteins
dc.subjectHyaluronic Acid
dc.subjectBone Remodeling
dc.titleIf good things come from above, do bad things come from below?
dc.typeJournal article
pubs.publication-statusPublished

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